Postdoctoral Position in Medicinal ChemistryPostdoctoral position is available to develop small molecule inhibitors for targeted therapies in cancer.
Postdoctoral Position in Medicinal ChemistryPostdoctoral position is available to develop small molecule inhibitors for targeted therapies in cancer.

Postdoctoral Position in Medicinal ChemistryPostdoctoral position is available to develop small molecule inhibitors for targeted therapies in cancer.

Postdoctoral Position in Medicinal ChemistryPostdoctoral position is available to develop small molecule inhibitors for targeted therapies in cancer. We are seeking for highly motivated postdoctoral fellow with very extensive knowledge and experience in medicinal chemistry and synthetic organic chemistry. The candidate will be involved in designing and synthesis of small molecule inhibitors targeting proteins as potential anti-cancer agents with a major focus on synthesis of heterocyclic compounds targeting protein-protein interactions relevant to cancer. The duties will include design and synthesis of new analogues of existing leads to develop SAR for different classes of lead compounds. The successful candidate must be independent in designing synthetic routes, solving challenging synthetic problems, efficient in synthesizing targeted molecules, analyzing results and SAR data to improve drug-like properties of synthesized compounds. The applicant needs to be experienced in using HPLC, NMR and MS for organic chemistry applications. Successful candidate will be a part of an interdisciplinary team whose research is focused on different stages of pre-clinical development of anti-cancer drug candidates, including biochemical studies, medicinal chemistry, structural biology, molecular modeling, cell-based experiments and animal studies Applicant must have PhD in medicinal chemistry, organic chemistry or related field. This position requires extensive experience and independence in designing synthetic routes for new classes of compounds, solving challenging synthetic problems, development of analogues for selected leads and SAR analysis. In addition expertise in molecular modeling, structure-based drug design and ADMET optimization would be a plus. Applicant needs an expertise in using HPLC, NMR and MS for organic chemistry applications. Furthermore, excellent oral and written communication skills in English are required. Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file. Contact: Jolanta Grembecka, PhD Assistant Professor Department of Pathology University of Michigan 4510 W. Medical Center Drive, MSRB I, 4510D Ann Arbor, MI, 48109, USA e-mail: jolantag@med.umich.edu Relevant publications: 1. Grembecka J, et al., Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol. 2012 Jan 29;8(3):277-84. 2. A. Shi, et al., Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, (2012), 120, 4481-9. 3. Grembecka J, et al., Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias. J Biol Chem. 2010 Dec 24;285(52):40690. Contact: Jolanta Grembecka, PhD Pathology University of Michigan 1301 Catherine St. 4510C MSRBI Ann Arbor, MI 48109 United States

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Postdoctoral Position in Medicinal ChemistryPostdoctoral position is available to develop small molecule inhibitors for targeted therapies in cancer. Postdoctoral Position in Medicinal ChemistryPostdoctoral position is available to develop small molecule inhibitors for targeted therapies in cancer.